Haematology : from the image to the diagnosis / Mike Leach, Barbara J. Bain.

By: Leach, Richard M. (Haematologist) [author.]
Contributor(s): Bain, Barbara J [author.]
Language: English Publisher: Hoboken, NJ : Wiley-Blackwell, 2022Description: 1 online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9781119777502; 9781119777526; 9781119777519Subject(s): Hematologic Diseases -- diagnosis | Blood Physiological PhenomenaGenre/Form: Examination Questions | Electronic books. | Case ReportsDDC classification: 616.1/5 LOC classification: RC636Online resources: Full text is available at Wiley Online Library Click here to view
Contents:
TABLE OF CONTENTS Preface Abbreviations 1. Haemophagocytic syndrome secondary to anaplastic large cell lymphoma 2. Bone marrow AL amyloidosis 3. Cup-like blast morphology in acute myeloid leukaemia 4. Neutrophil morphology 5. Primary myelofibrosis 6. Sarcoidosis 7. Leishmaniasis 8. Gelatinous transformation of the bone marrow 9. Acanthocytic red cell disorders 10. Large granular lymphocytic leukaemia 11. Pure erythroid leukaemia 12. Reactive mesothelial cells 13. Plasmablastic myeloma 14. Septicaemia 15. Unstable haemoglobin (haemoglobin Köln) and a myeloproliferative neoplasm 16. Sickle cell anaemia in crisis 17. Acute myeloid leukaemia with t(8;21)(q22;q22.1) 18. Chronic neutrophilic leukaemia 19. Essential thrombocythaemia 20. Hairy cell leukaemia 21. Mantle cell lymphoma in leukaemic phase 22. Infantile osteopetrosis 23. Reactive eosinophilia 24. Stomatocytic red cell disorders 25. Reactive lymphocytosis due to viral infection 26. Therapy-related acute myeloid leukaemia with eosinophilia 27. Red cell fragmentation syndromes 28. NK/T-cell lymphoma in leukaemic phase 29. Myelodysplastic syndrome with del(5q) 30. Classical Hodgkin lymphoma 31. Cryoglobulinaemia 32. Congenital dyserythropoietic anaemia 33. Acute monoblastic leukaemia with t(9;11)(p21.3;q23.3) 34. Chronic myeloid leukaemia presenting with myeloid sarcoma and extreme thrombocytosis 35. Glucose-6-phosphate dehydrogenase deficiency 36. Leukaemic presentation of hepatosplenic gamma-delta T-cell lymphoma 37. Myelodysplastic syndromes 38. Pelger–Huët anomaly 39. Russell bodies in lymphoplasmacytic lymphoma 40. T-cell prolymphocytic leukaemia 41. Myeloid maturation arrest 42. MDS/MPN with ring sideroblasts and thrombocytosis 43. Acute myeloid leukaemia with inv(16)(p13.1q22) 44. Babesiosis 45. Haemoglobin E disorders 46. Juvenile myelomonocytic leukaemia 47. Non-haemopoietic tumours 48. Richter transformation of chronic lymphocytic leukaemia 49. Sickle cell-haemoglobin C disease 50. T cell/histiocyte-rich B-cell lymphoma 51. Miliary tuberculosis 52. Pure red cell aplasia 53. Lymphoblastic transformation of follicular lymphoma 54. Primary hyperparathyroidism 55. Gamma heavy chain disease 56. Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.2) 57. AA amyloidosis 58. Acquired sideroblastic anaemia 59. Diffuse large B-cell lymphoma 60. Hickman line infection 61. Monocytes and their precursors 62. Paroxysmal cold haemoglobinuria 63. Transient abnormal myelopoiesis 64. Systemic lupus erythematosus 65. Granular blast cells in acute lymphoblastic leukaemia 66. Chronic myelomonocytic leukaemia 67. Burkitt lymphoma/leukaemia 68. Gaucher’s disease 69. Myelodysplastic syndrome with haemophagocytosis 70. Primary oxalosis 71. Acute myeloid leukaemia with inv(3)(q21.3q26.2) 72. Autoimmune haemolytic anaemia 73. Chronic eosinophilic leukaemia due to FIP1L1-PDGFRA fusion gene 74. Leukaemic phase of follicular lymphoma 75. Megaloblastic anaemia 76. Reactive bone marrow and an abnormal PET scan 77. Acute megakaryoblastic leukaemia 78. Erythrophagocytosis and haemophagocytosis 79. Hyposplenism 80. Acquired haemoglobin H disease 81. Cystinosis 82. Familial platelet disorder with a predisposition to AML 83. Nodular lymphocyte predominant Hodgkin lymphoma 84. Acute monocytic leukaemia with NPM1 mutation 85. Adult T-cell leukaemia/lymphoma 86. Hereditary elliptocytosis and pyropoikilocytosis 87. Sézary syndrome 88. Spherocytic red cell disorders 89. Acute myeloid leukaemia and metastatic carcinoma 90. Chédiak-Higashi syndrome 91. Cortical T-lymphoblastic leukaemia/lymphoma 92. Trypanosomiasis 93. Acute myeloid leukaemia with myelodysplasia-related changes 94. Blastic plasmacytoid dendritic cell neoplasm 95. Inherited macrothrombocytopenias 96. Persistent polyclonal B-cell lymphocytosis 97. Acute myeloid leukaemia with t(6;9)(p23;q34.1) 98. B-cell prolymphocytic leukaemia 99. Various red cell enzyme disorders 100. Sea blue histiocytosis in multiple myeloma 101. Enteropathy-associated T-cell lymphoma Answers to multiple choice questions and further reflections on the theme Index
Summary: "Despite the tremendous advances that have occurred in diagnostic haematopathology in recent decades haematology remains firmly based on a clinical assessment of the patient, on basic laboratory tests and on a critical assessment of peripheral blood and bone marrow films. In this book we seek to show how an appreciation of blood and bone marrow morphology, assessed with knowledge of the clinical context, can lead to a provisional or, sometimes, a definitive diagnosis that guides further investigation and management. Each of the 101 themes is followed by a related multiple choice question with the preferred answers and further discussion being found in the second part of the book. The themes are sometimes single cases and sometimes a composite of related cases. The book is directed at consultants and trainees in haematology and haematopathology and at clinical and biomedical scientists in these disciplines. We hope that readers will share our enjoyment of the constant sense of discovery that accompanies haematological morphology. All magnifications are stated in terms of the objective used. Common abbreviations that may be used without definition are given on pages xy. Other abbreviations are defined on first use in a theme. All images are of films stained with a May-Grünwald-Giemsa stain unless stated otherwise. The cases are not arranged thematically, since a more random arrangement better approximates to real life. We wish to thank our clinical and laboratory colleagues with whom we have collaborated over many years"-- Provided by publisher.
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EBOOK EBOOK COLLEGE LIBRARY
COLLEGE LIBRARY
616.15 L468 2022 (Browse shelf) Available CL-53014
Total holds: 0

ABOUT THE AUTHOR
About the Authors

Mike Leach, MB ChB, FRCP, FRCPath, is Consultant Haematologist and Honorary Senior Lecturer at the Haematology Laboratories and West of Scotland Cancer Centre in Gartnavel General Hospital, Glasgow, UK.

Barbara J. Bain, MB BS, FRACP, FRCPath, is Professor of Diagnostic Haematology at St Mary’s Hospital Campus, Imperial College London, and Consultant Haematologist at St Mary’s Hospital, London, UK.

Includes bibliographical references and index.

TABLE OF CONTENTS
Preface

Abbreviations

1. Haemophagocytic syndrome secondary to anaplastic large cell lymphoma

2. Bone marrow AL amyloidosis

3. Cup-like blast morphology in acute myeloid leukaemia

4. Neutrophil morphology

5. Primary myelofibrosis

6. Sarcoidosis

7. Leishmaniasis

8. Gelatinous transformation of the bone marrow

9. Acanthocytic red cell disorders

10. Large granular lymphocytic leukaemia

11. Pure erythroid leukaemia

12. Reactive mesothelial cells

13. Plasmablastic myeloma

14. Septicaemia

15. Unstable haemoglobin (haemoglobin Köln) and a myeloproliferative neoplasm

16. Sickle cell anaemia in crisis

17. Acute myeloid leukaemia with t(8;21)(q22;q22.1)

18. Chronic neutrophilic leukaemia

19. Essential thrombocythaemia

20. Hairy cell leukaemia

21. Mantle cell lymphoma in leukaemic phase

22. Infantile osteopetrosis

23. Reactive eosinophilia

24. Stomatocytic red cell disorders

25. Reactive lymphocytosis due to viral infection

26. Therapy-related acute myeloid leukaemia with eosinophilia

27. Red cell fragmentation syndromes

28. NK/T-cell lymphoma in leukaemic phase

29. Myelodysplastic syndrome with del(5q)

30. Classical Hodgkin lymphoma

31. Cryoglobulinaemia

32. Congenital dyserythropoietic anaemia

33. Acute monoblastic leukaemia with t(9;11)(p21.3;q23.3)

34. Chronic myeloid leukaemia presenting with myeloid sarcoma and extreme thrombocytosis

35. Glucose-6-phosphate dehydrogenase deficiency

36. Leukaemic presentation of hepatosplenic gamma-delta T-cell lymphoma

37. Myelodysplastic syndromes

38. Pelger–Huët anomaly

39. Russell bodies in lymphoplasmacytic lymphoma

40. T-cell prolymphocytic leukaemia

41. Myeloid maturation arrest

42. MDS/MPN with ring sideroblasts and thrombocytosis

43. Acute myeloid leukaemia with inv(16)(p13.1q22)

44. Babesiosis

45. Haemoglobin E disorders

46. Juvenile myelomonocytic leukaemia

47. Non-haemopoietic tumours

48. Richter transformation of chronic lymphocytic leukaemia

49. Sickle cell-haemoglobin C disease

50. T cell/histiocyte-rich B-cell lymphoma

51. Miliary tuberculosis

52. Pure red cell aplasia

53. Lymphoblastic transformation of follicular lymphoma

54. Primary hyperparathyroidism

55. Gamma heavy chain disease

56. Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.2)

57. AA amyloidosis

58. Acquired sideroblastic anaemia

59. Diffuse large B-cell lymphoma

60. Hickman line infection

61. Monocytes and their precursors

62. Paroxysmal cold haemoglobinuria

63. Transient abnormal myelopoiesis

64. Systemic lupus erythematosus

65. Granular blast cells in acute lymphoblastic leukaemia

66. Chronic myelomonocytic leukaemia

67. Burkitt lymphoma/leukaemia

68. Gaucher’s disease

69. Myelodysplastic syndrome with haemophagocytosis

70. Primary oxalosis

71. Acute myeloid leukaemia with inv(3)(q21.3q26.2)

72. Autoimmune haemolytic anaemia

73. Chronic eosinophilic leukaemia due to FIP1L1-PDGFRA fusion gene

74. Leukaemic phase of follicular lymphoma

75. Megaloblastic anaemia

76. Reactive bone marrow and an abnormal PET scan

77. Acute megakaryoblastic leukaemia

78. Erythrophagocytosis and haemophagocytosis

79. Hyposplenism

80. Acquired haemoglobin H disease

81. Cystinosis

82. Familial platelet disorder with a predisposition to AML

83. Nodular lymphocyte predominant Hodgkin lymphoma

84. Acute monocytic leukaemia with NPM1 mutation

85. Adult T-cell leukaemia/lymphoma

86. Hereditary elliptocytosis and pyropoikilocytosis

87. Sézary syndrome

88. Spherocytic red cell disorders

89. Acute myeloid leukaemia and metastatic carcinoma

90. Chédiak-Higashi syndrome

91. Cortical T-lymphoblastic leukaemia/lymphoma

92. Trypanosomiasis

93. Acute myeloid leukaemia with myelodysplasia-related changes

94. Blastic plasmacytoid dendritic cell neoplasm

95. Inherited macrothrombocytopenias

96. Persistent polyclonal B-cell lymphocytosis

97. Acute myeloid leukaemia with t(6;9)(p23;q34.1)

98. B-cell prolymphocytic leukaemia

99. Various red cell enzyme disorders

100. Sea blue histiocytosis in multiple myeloma

101. Enteropathy-associated T-cell lymphoma

Answers to multiple choice questions and further reflections on the theme

Index

"Despite the tremendous advances that have occurred in diagnostic haematopathology in recent decades haematology remains firmly based on a clinical assessment of the patient, on basic laboratory tests and on a critical assessment of peripheral blood and bone marrow films. In this book we seek to show how an appreciation of blood and bone marrow morphology, assessed with knowledge of the clinical context, can lead to a provisional or, sometimes, a definitive diagnosis that guides further investigation and management. Each of the 101 themes is followed by a related multiple choice question with the preferred answers and further discussion being found in the second part of the book. The themes are sometimes single cases and sometimes a composite of related cases. The book is directed at consultants and trainees in haematology and haematopathology and at clinical and biomedical scientists in these disciplines. We hope that readers will share our enjoyment of the constant sense of discovery that accompanies haematological morphology. All magnifications are stated in terms of the objective used. Common abbreviations that may be used without definition are given on pages xy. Other abbreviations are defined on first use in a theme. All images are of films stained with a May-Grünwald-Giemsa stain unless stated otherwise. The cases are not arranged thematically, since a more random arrangement better approximates to real life. We wish to thank our clinical and laboratory colleagues with whom we have collaborated over many years"-- Provided by publisher.

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